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Table 2 Cytokine and chemokines secretion levels in HC and ALS MDMi

From: ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

Analyte HCa ALSa P valueb
IL-8 (CXCL8) 3019 (n = 9, ± 2402) 9763 (n = 9, ± 6357) 0.0244*
IFNα2 1.34 (n = 9, ± 0.8) 3.23 (n = 9, ± 2.9) 0.1903
MCP-1 (CCL-2) 35,764 (n = 9, ± 26,947) 5795 (n = 9, ± 6031) 0.077
IL-6 80.31 (n = 7, ± 97) 1114 (n = 9, ± 2152) 0.2105
IL-1β 4.37 (n = 2, ± 3.2) 9.58 (n = 8, ± 7.5) 0.2667
IL-18 2.8 (n = 6, ± 0.7) 18.6 (n = 8, ± 13.6) 0.043*
IL-33 29.0 (n = 3, ± 2.2) 68.4 (n = 9, ± 49) 0.1364
IFNγ 0.5 (n = 1, ± 0) 2.97 (n = 9, ± 3.2) 0.4913
IL-10 3.54 (n = 1, ± 0) 10.44 (n = 2, ± 6) 0.5213
IL-23 14.77 (n = 6, ± 5.6) 185.1 (n = 2, ± 96) 0.0714
TNF-α 1.8 (n = 6, ± 1.4) 5.76 (n = 3, ± 0.94) 0.0031**
IL-17A Below limit of detection
IL-12p70
  1. aMean pg/ml (n, ± SD)
  2. bMann–Whitney U test, *P < 0.05, **P < 0.01