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Table 2 Cytokine and chemokines secretion levels in HC and ALS MDMi

From: ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

Analyte

HCa

ALSa

P valueb

IL-8 (CXCL8)

3019 (n = 9, ± 2402)

9763 (n = 9, ± 6357)

0.0244*

IFNα2

1.34 (n = 9, ± 0.8)

3.23 (n = 9, ± 2.9)

0.1903

MCP-1 (CCL-2)

35,764 (n = 9, ± 26,947)

5795 (n = 9, ± 6031)

0.077

IL-6

80.31 (n = 7, ± 97)

1114 (n = 9, ± 2152)

0.2105

IL-1β

4.37 (n = 2, ± 3.2)

9.58 (n = 8, ± 7.5)

0.2667

IL-18

2.8 (n = 6, ± 0.7)

18.6 (n = 8, ± 13.6)

0.043*

IL-33

29.0 (n = 3, ± 2.2)

68.4 (n = 9, ± 49)

0.1364

IFNγ

0.5 (n = 1, ± 0)

2.97 (n = 9, ± 3.2)

0.4913

IL-10

3.54 (n = 1, ± 0)

10.44 (n = 2, ± 6)

0.5213

IL-23

14.77 (n = 6, ± 5.6)

185.1 (n = 2, ± 96)

0.0714

TNF-α

1.8 (n = 6, ± 1.4)

5.76 (n = 3, ± 0.94)

0.0031**

IL-17A

Below limit of detection

IL-12p70

  1. aMean pg/ml (n, ± SD)
  2. bMann–Whitney U test, *P < 0.05, **P < 0.01