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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology

Fig. 9

Coupling of microglial Aβ42 phagocytosis with DAM formation. a Representative image for Aβ42 (purple), LPL (red) with Iba1 (green) immunostaining in the cortex after Aβ42 injection. Scale bar = 10 μm. b Representative images for Aβ42 (purple), Clec7a (red) with Iba1 (green) immunostaining in the cortex after Aβ42 injection. Scale bar = 10 μm. c Bar plot showing the fraction of IBA1+ cells in the injected site and un-injected site (n = 3 male mice per group). d Quantification of the correlation between the fluorescence intensity of Iba1+Aβ+ and fluorescence intensity of Iba1+LPL+

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