Fig. 4

LXRs activation improves indices of age-related neuropathic pain. A Change in mechanical allodynia in 24 month-old mice treated with and without LXRs agonist GW3965 for 12 weeks (n = 10–12/group). B Change in thermal hyperalgesia in 24-month-old mice treated with and without LXRs agonist GW3965 for 12 weeks (n = 6/group). Distal nerve quantification in 24-month-old mice treated with and without LXRs agonist GW3965, IENF C and SBNP D (n = 4–5/group). E Representative images of paw plantar skin of 24-month-old mice treated with and without LXRs agonist GW3965 used for IENF quantification. PGP9.5 positive nerve fibers stain brown. Black arrows indicate intra-epidermal nerve fibers and arrowheads indicate dermal nerves. All images were obtained at 40 × magnification. All data are Mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.0005