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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Fig. 3

Cx43 protein expression patterns are altered in the hippocampus of mice exposed to long-term isoflurane anesthesia. a Representative protein bands shown for different configurations of Cx43 (upper panel) and their quantification (lower panel) are presented on day 1 post-anesthesia (n = 6/group). Representative bands of three mice per group were illustrated. b Representative bands shown for different configurations of Cx43 (upper panel) and their quantification (lower panel) are presented on day 3 post-anesthesia (n = 6/group). Representative bands of three mice per group were illustrated. c Representative bands shown for different configurations of Cx43 (upper panel) and their quantification (lower panel) are presented on day 7 post-anesthesia (n = 6/group), and three representative samples per group are shown. Representative fluorescent micrographs from the CA3 region of hippocampus (d) and quantification of GJs-Cx43 puncta (e) on day 1 post-anesthesia (n = 6/group). Representative fluorescent micrographs from the CA3 region of hippocampus (f) and quantification of GJs-Cx43 puncta (g) on day 3 post-anesthesia (n = 6/group). Representative fluorescent micrographs from the CA3 region of hippocampus (h) and quantification of GJs-Cx43 puncta (i) on day 7 post-anesthesia (n = 6/group). Data are presented as the mean ± SEM. Student’s t-test was used for statistical analysis. *p < 0.05; **p < 0.01; ***p < 0.001

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