Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

Fig. 2

Cellular localization of inflammasome components after sciatic nerve axotomy in the spinal cord. a NLRP3 expression in the ventral horn of the contralateral side, and of the injured side 1, 3 and 7 days following unilateral sciatic nerve axotomy. Dashed lines represent grey-white matter transition. b Colocalization of NLRP3 and ASC in motoneurons labeled with ChAT 3 days following nerve injury. Arrows point at NLRP3-ASC-positive motoneurons. c NLRP3 expression in GFAP-positive astroglia at 7 days following axotomy. Coexpression of NLRP3 and ASC was not observed in astroglia, as represented by dashed arrows. d Microglial NLRP3 around injured motoneurons 7 days after axotomy. NLRP3-positive microglia were mostly ASC-negative (dashed arrows); however, NLRP3-ASC-positive microglial cells were also sparsely observed (solid arrow)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094