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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

Fig. 4

Effect of MCC950 and IL-1β neutralization on microglial activation in the spinal cord after axotomy. ae Microglial reaction, as assessed with Iba1 IHC, in the spinal cord 3 days post-injury. f Quantification of microglial reaction in the ventral horn 3 days following axotomy. Results are represented as the difference between the percentage of stained area on the injured and control sides. N = 4 animals/group. ***p < 0.001 (ANOVA with Fisher’s LSD post hoc, compared to ax. + vehicle), ##p < 0.01 (ANOVA with Fisher’s LSD post hoc, compared to ax. + goat IgG). gk Microglial activation in the spinal cord 7 days post-injury. l Quantification of microglial reaction 7 days after the axotomy. Results are represented as the difference of stained areas, similarly to (f). N = 4 animals/group. Significance marks are the same as for (f). Mean values are shown on all bars. Bars represent average ± SEM. Ax. axotomy

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