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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

Fig. 8

Effect of MCC950 on axonal regrowth 5 days after sciatic nerve axotomy and coaptation. ad Confocal images of injured sciatic nerves stained with the Schwann cell marker p75 and the axonal marker NEFM. Animals were treated with vehicle (a), MCC950 (b), goat IgG c or IL-1β neutralizing antibody (d). e Quantification of regrowing axons 5 days after sciatic nerve injury. Bars represent the average number of regrowing axons and their distance relative to the zone of coaptation. N = 3–4 animals/group. f Graph representing the sum of regrowing axons derived as multiplication of axonal length and number of axons (i.e., area under the curve of graph (e)). Mean values are shown on bars. Bars represent average ± SEM. N = 3–4 animals/group. *p < 0.05 compared to vehicle-treated animals, #p < 0.05 compared to mice receiving goat IgG (Student’s paired t-test). Coapt. axotomy + coaptation, IL-1β neutr. IL-1β neutralization, a.u. arbitrary unit

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