Fig. 5

Homer1-OE increased the proportion of S100A10⁺GFAP⁺ cells and improved behavioral score and survival time. A Representative photographs of C3 and GFAP co-staining of frozen sections of brain tissue in different groups 3 days after intracerebral hemorrhage. B Representative photographs of S100A10 and GFAP co-staining of frozen sections of brain tissue in different groups 3 days after intracerebral hemorrhage. C Quantification of result in panel A [F (3, 16) = 167.3, P < 0.0001]. D Quantification of result in panel B [F (3, 16) = 122.0, P < 0.0001]. E expression of TNF-α [F (3, 16) = 223.6, P < 0.0001]. F expression of IL-1β [F (3, 16) = 352.4, P < 0.0001]. G Longa scores of different groups on the 3rd day after ICH [F (3, 36) = 69.85, P < 0.0001]. H Survival curve of mice in each group (n = 20) after ICH operation [log-rank (Mantel–Cox) test: Chi-square = 40.81; df = 3; P < 0.0001]. The data were analyzed using one-way analysis of variance and all data are expressed as the mean ± standard deviation. *P < 0.05 represents a statistically significant difference between the two groups