Fig. 8

Ebselen prevents cigarette smoke (CS)-induced synaptophysin deficits. A Protein carbonylation (main effect of exposure: F_(1,28) = 10.26, p = 0.0034; n = 6 per group); B lipid peroxidation (main effect of exposure: F_(1,5) = 12.37, p = 0.018; n = 6 per group); C gene expression of oxidative markers in the hippocampus (NADPH oxidase [Nox1]: main effect of exposure: F_(1,5) = 350.46, p = 0.0019; Nox4: main effect of exposure: F_(1,5) = 6.819, p = 0.0476; Nitric oxide synthase [Nos2 / iNos]: main effect of exposure: F_(1,5) = 9.311, p = 0.0028; Glutathione peroxidase [Gpx]1: main effect of treatment: F_(1,5) = 29.72, p = 0.0028; n = 6 per group). D Synaptophysin labelling in the dentate gyrus hilus region of the hippocampus (F_(1,7) = 17.42, p = 0.0042; n = 7–8 per group). Data are expressed as mean + SEM. * p < 0.05; ** p < 0.01