Table 2 Top 20 up- and down-regulated DEGs in subretinal fibrosis mice
From: Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
Symbol | log2(fc) | FDR | Description of function |
|---|---|---|---|
Up-regulated DEGs | |||
Gm2000 | 3.098 | 0.00001 | Translation |
Stra6l | 2.741 | 0.01272 | Retinol transport and vitamin A import |
Mmp12 | 2.547 | 0.00000 | Tissue remodelling |
Aard | 2.428 | 0.00277 | Development |
Madcam1 | 2.289 | 0.00350 | Cell–matrix adhesion |
Gm49339 | 2.119 | 0.00595 | Neutrophil homeostasis |
Atp6v0d2 | 1.959 | 0.00000 | Ion transport |
Il7r | 1.918 | 0.00069 | Cytokine receptor activity |
Gm13889 | 1.798 | 0.00279 | Data not shown (predicted gene) |
Aplnr | 1.771 | 0.00007 | Angiogenesis |
Rfxap | 1.768 | 0.00399 | Positive regulation of transcription |
Chil1 | 1.715 | 0.00000 | Chitin binding activity |
Jund | 1.678 | 0.00000 | Cells protection from senescence and apoptosis |
Smarcd3 | 1.676 | 0.00000 | Heart morphogenesis, neural retina development |
Dexi | 1.669 | 0.00062 | Protein binding |
Ctss | 1.663 | 0.00000 | Collagen binding |
Mpnd | 1.579 | 0.00000 | Chromatin remodeling |
Lyz2 | 1.543 | 0.00000 | Lysozyme activity |
Bcan | 1.539 | 0.00277 | Calcium ion binding |
Tlr13 | 1.501 | 0.00134 | Protein binding activity and rRNA binding activity |
Down-regulated DEGs | |||
Crygb | − 4.135 | 0.00595 | Eye development |
Nr4a1 | − 2.825 | 0.00481 | DNA-binding transcription activator activity |
Egr3 | − 2.405 | 0.02232 | DNA-binding transcription activator activity |
Gm20075 | − 2.225 | 0.00614 | Data not shown(predicted gene) |
Arc | − 2.222 | 0.00273 | mRNA binding activity |
Gpr139 | − 2.039 | 0.00008 | Protein binding activity, neuropeptide receptor activity |
Sik1 | − 1.630 | 0.00435 | ATP binding activity,enzyme binding activity |
Gzmm | − 0.930 | 0.00013 | T cell mediated cytotoxicity |
Map6d1 | − 0.878 | 0.00205 | Calmodulin binding activity,microtubule binding activity |
Krt23 | − 0.841 | 0.00426 | Structural molecule activity |
Spry2 | − 0.833 | 0.00076 | Negative regulation of cell differentiation |
Adora2b | − 0.785 | 0.00001 | G protein-coupled receptor activity |
Fam13a | − 0.764 | 0.00587 | GTPase activator activity |
Ermap | − 0.759 | 0.00098 | Signaling receptor binding activity |
Rrh | − 0.736 | 0.00007 | Protein-coupled photoreceptor activity, Phototransduction |
Rd3l | − 0.733 | 0.00824 | Visual perception |
Htr3a | − 0.729 | 0.02029 | Protein binding activity |
Dusp6 | − 0.714 | 0.00669 | Negative regulation of protein phosphorylation |
Upk3b | − 0.701 | 0.01424 | Negative regulation of glucose import |
Mogat1 | − 0.698 | 0.04907 | Lipid metabolic process |