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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

Fig. 5

Analysis of up-regulated pathways uncovers HSV-1-mediated pro-inflammatory response of “in transition” microglia/microglia-like cells during HSE. a Feature plots show the distribution of the top three cluster-specific genes with the highest expression levels on two-dimensional UMAP (td-UMAP) visualization of aggregated data (three infected and two uninfected mice on day 6 p.i.). Csmd3, Slc2a5, P2ry12 for microglia, Sirpb1c, Ly6i, Apoc2 for infiltrating monocytes, and G0s2, Il1f9, Hdc for “in transition” microglia/microglia-like cells. b Homemade heatmap shows increased levels of IFN-stimulated genes involved in antiviral response for “in transition” microglia/microglia-like cells. c Dot plots showing the first 25 most significantly up-regulated Reactome pathways in monocytes and microglial cell sub-clusters. The size of each dot represents the number of genes in each cell sub-cluster, and the color of each dot indicates the normalized enrichment score of each pathway (p-adjust). Pathways that were not significantly enriched (Q value ≥ 0.05, Benjamini–Hochberg correction) are not displayed

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Journal of Neuroinflammation

ISSN: 1742-2094