Skip to main content
Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Fig. 6

Irisin promotes the phenotype of microglia/macrophage from pro-inflammatory into anti-inflammatory at 72 h post-ICH. A Representative double immunofluorescence staining for Iba1 (green) and CD16 (red) in the perihematomal area. Scale bar = 50 μm. B Representative images of Iba1 (green) and CD206 (red) immunostaining in the perihematomal area. Scale bar = 50 μm. CE Quantitative analyses of Iba1+ microglia/macrophage, Iba1+/CD16+ M1 microglia/macrophage and Iba1+/CD206+ M2 microglia/macrophage in the perihematomal area at 72 h after ICH. F M1-associated mRNA levels were evaluated including CD16, CD32, IL-1β, iNOS, IL-6, and CD11b. G M2-associated mRNA levels were evaluated including CD206, Arg1, CCL22, TGF-β, IL-13, and YM1/2. Data were represented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham group; #p < 0.05, ##p < 0.01 vs. ICH + vehicle group. One-way ANOVA, Tukey test, n = 6/group

Back to article page