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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Fig. 7

Integrin αVβ5 inhibition reverses the effects of irisin on neurological functions and inflammatory/apoptotic proteins expression at 24 h after ICH. AC Modified Garcia test, forelimb placement test, and corner turn test. D Representative western blot images and quantitative analyses of integrin αV, integrin β5, p-AMPK/AMPK, IL-1β, TNF-α, MPO, Bax and Bcl-2 at 24 h post-ICH. Values are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham group; #p < 0.05, ##p < 0.01 vs. ICH + vehicle group; @p < 0.05, @@p < 0.01 vs. irisin + DMSO group. Data was represented as mean ± SD. One-way ANOVA, Tukey test, n = 6/group

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