Fig. 3

Changed proteins in CSF of patients with JE subgroups. A PCA score plot in all CSF samples based on detected proteins. Apart from the control group, all plots in JEI and JEII were clustered together, respectively, and each group (control, JEI, and JEII) could be easily differentiated. B Association between protein expression (JE/Con ratio) and confidence level. A list of 25 overexpressed proteins with log-rank P value < 0.05 and log₂ (JE/Con ratio) > 1.58 and 36 downregulated proteins with log-rank P value < 0.05 and log₂ (JE/Con ratio) < − 1.58 in JE are included in the box on the left and right. C. Differentially expressed proteins between JE2 and JE1 were mainly clustered on protein functions such as myeloid leukocyte-mediated immunity, antibody protein expression, and cell morphogenesis involved in neuron differentiation