Table 2 Risk of clinical outcomes according to quartiles of sTREM2 in the acute phase of ischemic stroke
| Â | sTREM2, pg/mL | p trend | |||
|---|---|---|---|---|---|
 < 247.45 | 247.45–401.27 | 401.27–651.60 |  ≥ 651.60 | ||
Median (pg/mL) | 172.16 | 323.62 | 503.15 | 901.40 | Â |
The primary outcome: death or cardiovascular events | |||||
 No. of cases (%) | 56 (6.8) | 63 (7.7) | 66 (8.0) | 103 (12.6) |  < 0.001 |
 Unadjusted HR | 1.00 | 1.13 (0.79–1.61) | 1.19 (0.83–1.70) | 1.93 (1.40–2.68) |  < 0.001 |
 Multiple-adjusted HR* | 1.00 | 1.01 (0.70–1.46) | 1.01 (0.70–1.45) | 1.57 (1.11–2.21) | 0.002 |
Death | |||||
 No. of cases (%) | 32 (3.9) | 31 (3.8) | 45 (5.5) | 78 (9.5) |  < 0.001 |
 Unadjusted HR | 1.00 | 0.97 (0.59–1.59) | 1.43 (0.91–2.24) | 2.56 (1.69–3.86) |  < 0.001 |
 Multiple-adjusted HR * | 1.00 | 0.76 (0.46–1.25) | 1.06 (0.67–1.69) | 1.68 (1.09–2.60) |  < 0.001 |
Cardiovascular events | |||||
 No. of cases (%) | 39 (4.7) | 47 (5.7) | 40 (4.9) | 54 (6.6) | 0.19 |
 Unadjusted HR | 1.00 | 1.21 (0.79–1.85) | 1.04 (0.67–1.61) | 1.46 (0.97–2.21) | 0.09 |
 Multiple-adjusted HR * | 1.00 | 1.14 (0.74–1.75) | 0.97 (0.62–1.52) | 1.36 (0.88–2.10) | 0.17 |
Death or severe disability | Â | Â | Â | Â | Â |
 No. of cases (%) | 76 (9.4) | 97 (12.1) | 103 (13.0) | 145 (18.6) |  < 0.001 |
 Unadjusted OR | 1.00 | 1.32 (0.96–1.81) | 1.43 (1.05–1.96) | 2.19 (1.63–2.95) |  < 0.001 |
 Multiple-adjusted OR * | 1.00 | 1.14 (0.80–1.64) | 1.09 (0.76–1.56) | 1.53 (1.08–2.18) | 0.01 |
Severe disability | Â | Â | Â | Â | Â |
 No. of cases (%) | 44 (5.7) | 66 (8.5) | 58 (7.8) | 67 (9.5) | 0.01 |
 Unadjusted OR | 1.00 | 1.55 (1.04–2.30) | 1.40 (0.93–2.09) | 1.75 (1.18–2.59) | 0.02 |
 Multiple-adjusted OR* | 1.00 | 1.39 (0.90–2.15) | 1.10 (0.71–1.72) | 1.40 (0.90–2.19) | 0.29 |