Fig. 5
From: The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Distinct global leukocyte landscapes in the brain of GFAP-IL6 versus GFAP-IFN mice. a UMAP plot of entire dataset (brains of MacGreen-WT, -GFAP-IL6 and -GFAP-IFN mice at 1, 3 and 6 months of age) labeled with FlowSOM cluster identities. b UMAP plots of the 6-month-old dataset split into WT, GFAP-IL6 and GFAP-IFN mice. c UMAP plots of the same dataset colored by the expression of TMEM119, CD11b, CD16/32 or CD64. d Cluster overlay of CD16/32 versus CD64 levels on the surface of microglia from the brains of WT, GFAP-IL6 and GFAP-IFN mice at 1, 3 and 6 months of age. n = 3–5 mice/group