Fig. 7
From: The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Meta-analysis of microglia gene expression datasets identified core and cytokine-specific co-regulated gene clusters. a Heatmap of z-scores (within-study-normalized) for 1,759 genes differentially expressed in at least 4 comparisons. Hierarchical clustering identified 22 clusters of co-regulated genes. b Summary of gene set changes from the meta-analysis, which identified upregulated danger response genes (clusters 2 and 9), downregulated danger response genes (clusters 1, 8 and 22), chronic response genes (cluster 7), IL-6-response genes (cluster 19) and IFN-response genes (clusters 5, 12 and 14). Differential expression was calculated by comparing each condition with its respective control. The median log2-fold change for each gene cluster is shown