Fig. 1
From: CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study
Overview of study design. There exist three significant assumptions for Mendelian randomization (MR). Assumption 1: Genetic instruments should be robustly associated with the exposure. Assumption 2: Genetic instruments should not be associated with any confounders. Assumption 3: Genetic instruments influence risk of the outcome through the exposure, rather than through other pathways. (CSF cerebrospinal fluid, GWAS genome-wide association study, LD linkage disequilibrium, SNP single nucleotide polymorphism, IS ischemic stroke, LAA large artery atherosclerosis, SVS small vessel stroke, CES cardioembolic stroke, ICH intracerebral hemorrhage, SAH subarachnoid hemorrhage, AD Alzheimer's disease, PD Parkinson's disease, ALS amyotrophic lateral sclerosis, MS multiple sclerosis, EP epilepsy)