Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation

Fig. 1

NLRP3 inflammasome is activated in neurons in SDH of IC rats, and MCC950 inhibits the NLRP3 inflammasome activation. A–E Western blot analysis showing that expression levels of NLRP3, Caspase-1, IL-1β and IL-18 were significantly increased in SDH of IC rats compared with normal rats, and MCC950 treatment significantly decreased expression levels of NLRP3, Caspase-1, IL-1β and IL-18 in SDH of IC rats. n = 8 per group. *P < 0.05. F Immunofluorescence co-staining showing that NLRP3 was colocalized predominantly with NeuN (neuron marker), but scarcely with GFAP (astrocyte marker) or OX-42 (microglia marker) in the SDH. Scale bars = 200 μm

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094