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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation

Fig. 3

NLRP3 inflammasome activation is related to mechanical allodynia and frequent micturition in IC rats. A von Frey test showing that suprapubic mechanical withdrawal threshold of IC rats was significantly lower than normal rats, and MCC950 treatment significantly raised suprapubic mechanical withdrawal threshold of IC rats. n = 10 per group. B, C Urodynamic evaluation showing that IC rats exhibited significantly shorter micturition interval than normal rats, and MCC950 treatment significantly prolonged the micturition interval of IC rats. n = 6 per group. *P < 0.05

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