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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1

Fig. 8

Schematic model of NLRX1-mediated insufficient mitophagy in morphine-treated microglial cells. Morphine enhanced the ability of NLRX1-mediated mitophagy in a LC3-dependent manner, while impairing lysosomal function including generation, mitophagosome–lysosome fusion and acidification, thus leading to disturbance of mitochondrial–lysosomal homeostasis. NLRX1-mediated incomplete mitophagy in morphine-treated microglial cells ultimately contributed to microglial immunosuppressive condition

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