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Table 1 Comparison between features of classically activated (M1) and alternatively activated (M2) macrophages

From: The macrophage: a key player in the pathophysiology of peripheral neuropathies

  1. ECM extracellular matrix, LPS lipopolysaccharide, IFN interferon, TNF tumour necrosis factor, IL interleukin, CXCL chemokine (C-X-C motif) ligand, CCL C–C motif chemokine ligand, TGF transforming growth factor; ROS reactive oxygen species, iNO inducible nitric oxide, VEGF vascular endothelial growth factor, Arg-1 arginase-1, Treg regulatory T lymphocyte, pSTAT phosphorylated signal transducer and activator of transcription, TLR toll-like receptor, iNOS inducible nitric oxide synthase, FIZZ1 found in inflammatory zone 1