Fig. 1
From: Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia
Tibial surgery leads to cognitive decline and LCN2 elevation in hippocampus. a Upper panel, cartoon depicting the TFC behavior paradigm. Lower panel, percent of time spent in freezing behavior (n = 12 mice/group). b Upper panel, cartoon depicting the NOR test paradigm. Lower panel, discrimination ratio during novel phase (n = 8 mice in Sham group, n = 7 mice in Surgery group). c Upper panel, samples were collected in another cohort at time points of 6 h, 24 h and 3 days, respectively. Lower panel, relative expression of Lcn2 mRNA at 6 h after surgery (n = 5 mice/group). d Tissue ELISA test of LCN2 in hippocampus (n = 3–6 mice/group). e LCN2 level correlates with IL-6 level in hippocampus at 6 h. Data are represented as mean ± SEM, * P < 0.05, ** P < 0.01; *** P < 0.001