Fig. 4
From: Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia
LCN2 mediates cognitive dysfunction after surgery. a Upper, scheme timeline for rLCN2 intracranial injection and TFC behavior test; lower, percent of time spent in freezing behavior (n = 8 mice in Vehicle group, n = 9 in rLCN2 group). Vehicle: PBS buffer. b Upper, constructs of the LCN2-AAV and Control-AAV; lower, scheme timeline for TFC behavior test and sample collections. c Relative expression of Lcn2 mRNA at 6 h after surgery (n = 5 mice/ group). d Tissue ELISA of LCN2 level in hippocampus at 6 h after surgery (n = 5 mice/group). e Percent of time spent in freezing behavior (n = 12 mice/group). Data are represented as mean ± SEM, * P < 0.05; ** P < 0.01