Fig. 4
From: Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke
Changes of SPAK–NKCC1 signaling complex and NF-kB activation in the ChP after stroke. a and c Pearson correlation analysis between pSPAK and Claudin-5 or Claudin-1 fluorescence intensity in the IL ChP (from the data presented in Fig. 3a–d). b and d Pearson correlation between pNKCC1 and Claudin-5 or Claudin-1 fluorescence intensity in the IL ChP. n = 24. e Western blot analysis of pNF-κB p65, NF-κB p65, and MMP9 protein expression in the IL LVCP of Sham, stroke Veh-control, ZT-1a- or BMT-treated mice at 24 h Rp. ChP tissue lysates were subjected to immunoblotting with the indicated antibodies. f Immunoblot quantitation. Data are mean ± SD (n = 4, 2 male, 2 female). *p < 0.05, ***p < 0.001, ****p < 0.0001. One-way ANOVA