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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: SUN11602, a bFGF mimetic, modulated neuroinflammation, apoptosis and calcium-binding proteins in an in vivo model of MPTP-induced nigrostriatal degeneration

Fig. 3

Effect of SUN11602 on DAT expression. MPTP-intoxicated mice showed a significant decrease of DAT expression in substantia nigra (B, B1, score F) compared to the Sham group (A, A1, score F). SUN11602 administration, at the doses of 2.5 (D, D1, score F) and more meaningfully at 5 mg/kg (E, E1, score F) resulted neuroprotective. SUN11602 1 mg/kg didn’t demonstrate significant efficacy (C, C1, score F). MPTP group showed a significant reduction of DAT expression in the striatum (H, H1, score M), compared to the Sham group (G, G1, score M). Dose-dependent response to DAT recovery was detected following treatment with SUN11602 (J, J1, K, K1, L, L1, score M). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; #p < 0.05 vs MPTP; ###p < 0.001 vs MPTP

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