Fig. 7

SUN11602 administration reduced neuroinflammation after MPTP injection. Western Blot analysis revealed a decreased expression of IĸB-α in MPTP-injected mice, compared to the Sham group (A, densitometric analysis A1). NF-kB levels resulted elevated in the MPTP-intoxicated mice compared to Sham animals (B, densitometric analysis B1). The anti-inflammatory effects of SUN11602 5 mg/kg were confirmed by increased IKB-α levels and at the same time by reduced NF-kB expression (A, A1; B, B1). A significant upregulation of pro-inflammatory cytokines expression was detected in the MPTP group, compared to the Sham mice (C–F, densitometric analysis C1–F1). These expressions were considerably reduced following SUN11602 5 mg/kg treatment (C–F, densitometric analysis C1–F1). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; _##p < 0.01 vs MPTP; ^###p < 0.001 vs MPTP