Fig. 9

SUN11602 administration modulated apoptosis after MPTP injection. Midbrain section obtained by MPTP-injected mice exposed high expression of p53 (B, score D), compared to the Sham animals (A, score D). SUN11602 5 mg/kg treatment demonstrated a significant reduction in p53 levels (C, score D). MPTP-intoxicated mice displayed increased expression of Bax and Caspase-3 and diminished levels of Bcl-2, compared to the Sham group (E, densitometric analysis E1; F, densitometric analysis F1; G, densitometric analysis G1). SUN11602 5 mg/kg administration reduced the expression of Bax and Caspase-3 while increasing Bcl-2 levels (E, densitometric analysis E1; F, densitometric analysis F1; G, densitometric analysis G1). Data are representative of at least three independent experiments. Values are means ± SEM. One-way ANOVA test. ***p < 0.001 vs Sham; ###p < 0.001 vs MPTP