Fig. 7

IL-13 is the key factor behind the beneficial effects of IL-13 Mφs in vivo. a IL-4Rα WT or KO BALB/c mice received vehicle or IL-13 Mφs immediately following injury. Functional recovery was improved by transplantation of IL-13 Mφs in WT mice but not in IL-4Rα KO mice. Data are shown as mean ± SEM. n = 6–12 mice/group. *WT + IL-13 Mφs versus vehicle. Two independent experiments. b C57BL/6J mice received vehicle or Arg-1 Mφs immediately following injury. No difference in functional recovery was observed between experimental groups. Data are shown as mean ± SEM. n = 10–12 mice/group. One independent experiment. Two-way ANOVA with Bonferroni post hoc test. *P < 0.05, **P < 0.01