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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems

Fig. 1

IMGL are the in vitro cell cultures that best resemble the transcriptional profile of human microglia. Bulk RNA-seq was performed in different innate immune in vitro cell cultures and compared to already published data from related cell types. a Principal component analysis demonstrates that IMGL (light and dark turquoise) is the cell type that clusters most closely to cultured human fetal and adult microglia (dark and light blue). In addition, these cells are distinct from human CD14 + monocytes (light pink) and CD16 + inflammatory monocytes (medium purple), and dendritic cells (dark purple). PBMC Mφ (red) and THP-1 cells (orange) are next in similarity and surprisingly the microglia HMC3 cell line (light purple) clusters more closely to the astrocytoma U-87 cell line (mustard) than to any microglia cell type analyzed. b The analysis of normalized counts of a subset of microglia markers show similar trends

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