Fig. 2

ZIKV infection impacts transcriptional pathways associated with fundamental neurobiological processes. A, B Selected overrepresented GO terms obtained from GO enrichment analysis of DEGs resulting ZIKV-MR766 infection in primary cortical neurons. Tabular results (A) are graphically represented in a bubble plot (B) to demonstrate associations between fold enrichment, FDR, and number of associated genes for each GO term. C–E Heatmaps depicting expression values for genes associated with regulation of behavior (C), neuropeptide signaling pathway (D), and neurogenesis (E). Data in (C), (D) and (E) represent normalized and z-transformed expression values