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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury

Fig. 5

Schwann cell gene changes post-crush. A–C Volcano plots of purified Schwann cells at day 3, 5, or 7 post-crush as compared to Schwann cells purified from uncrushed nerves. D–F Enriched pathways in Schwann cells from each timepoint based on Gene Ontogeny (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway analysis of the top 2000 most upregulated genes at each post-crush timepoint (all genes with padj < 0.05). G Most enriched pathways (or GO categories) at day 3, 5 and 7. GO terms were binned across each time point, with the top five most frequently observed terms presented here. Direction of arrows highlight that some pathways, e.g., cell division and cell cycle arrest, decrease with time post-crush, while others (cytoskeletal rearrangement) peak at intermediate timepoints post-injury

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