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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Epigenetic regulation of innate immune memory in microglia

Fig. 1

LPS desensitization and accelerated aging result in distinct changes of the microglia immune response. a Graphic representation of the mouse models and treatment groups. A pure microglia population was isolated by FACS and subjected to RNA, ATAC, and ChIP-sequencing analysis. b, c Four-way plots depicting changes in gene expression in microglia isolated from LPS-injected naive and pre-conditioned mice (n = 3 per experimental condition) (b) and Ercc1Δ/ko and control mice (n = 3 per experimental condition) (c). Every gene is represented by an individual dot. Differentially expressed genes (LogFC > 2) are labeled with different colors indicating their respective expression changes. Dark blue dots indicate genes differentially expressed in both comparisons; turquoise (PL versus PP and WT-LPS versus WT-PBS) and lavender (LL versus PP and KO-LPS versus KO-PBS) dots represent genes differentially expressed in one of the comparisons. Several relevant genes are highlighted. d, e The number of differentially expressed genes (LogFC > 1 and FDR < 0.01) between treatment groups in the endotoxin tolerance (d) and Ercc1Δ/ko-induced microglia priming models (e). Upward arrows indicate increased gene expression, downward arrows indicate decreased gene expression in the condition where the large arrow points to

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