Marker and levels * | Events [no., (%)] | Model 1†| Model 2‡ | Model 3§ | Model 4|| | |||||
---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
IL-6 (ng/L) | Q1 | 213 (8.1) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 212 (8.1) | 1.00 (0.83–1.21) | 0.99 | 0.92 (0.76–1.11) | 0.38 | 0.91 (0.75–1.11) | 0.34 | 0.90 (0.74–1.10) | 0.30 | |
Q3 | 262 (10.0) | 1.25 (1.04–1.49) | 0.02 | 1.07 (0.89–1.29) | 0.47 | 1.10 (0.90–1.32) | 0.37 | 1.08 (0.89–1.30) | 0.46 | |
Q4 | 339 (13.0) | 1.69 (1.42–2.00) | < 0.0001 | 1.35 (1.12–1.62) | 0.002 | 1.37 (1.14–1.66) | 0.001 | 1.36 (1.13–1.64) | 0.001 | |
Continuous model | 1.32 (1.23–1.41) | < 0.0001 | 1.21 (1.12–1.30) | < 0.0001 | 1.21 (1.12–1.31) | < 0.0001 | 1.21 (1.12–1.31) | < 0.0001 | ||
IL-1Ra (ng/L) | Q1 | 238 (9.1) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 249 (9.5) | 1.05 (0.88–1.26) | 0.57 | 1.01 (0.85–1.21) | 0.91 | 1.02 (0.85–1.22) | 0.84 | 1.02 (0.85–1.22) | 0.84 | |
Q3 | 282 (10.8) | 1.21 (1.02–1.43) | 0.03 | 1.10 (0.92–1.31) | 0.31 | 1.10 (0.92–1.31) | 0.32 | 1.09 (0.91–1.31) | 0.34 | |
Q4 | 257 (9.8) | 1.11 (0.93–1.32) | 0.25 | 0.98 (0.82–1.18) | 0.85 | 1.00 (0.83–1.21) | 0.98 | 0.98 (0.81–1.19) | 0.85 | |
Continuous model | 1.09 (0.99–1.20) | 0.09 | 1.03 (0.93–1.14) | 0.60 | 1.03 (0.93–1.15) | 0.53 | 1.03 (0.92–1.14) | 0.63 | ||
hsCRP (mg/L) | Q1 | 212 (8.1) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 218 (8.4) | 1.05 (0.87–1.27) | 0.63 | 1.03 (0.85–1.24) | 0.79 | 1.03 (0.85–1.26) | 0.74 | 1.03 (0.85–1.25) | 0.77 | |
Q3 | 264 (10.1) | 1.28 (1.07–1.53) | 0.007 | 1.20 (1.00–1.44) | 0.05 | 1.20 (0.99–1.44) | 0.07 | 1.18 (0.98–1.42) | 0.09 | |
Q4 | 332 (12.7) | 1.66 (1.40–1.98) |  < 0.0001 | 1.42 (1.19–1.70) | 0.0001 | 1.42 (1.18–1.71) | 0.0002 | 1.41 (1.17–1.69) | 0.0003 | |
Continuous model | 1.15 (1.11–1.20) | < 0.0001 | 1.10 (1.05–1.15) | < 0.0001 | 1.10 (1.05–1.16) | < 0.0001 | 1.10 (1.05–1.15) | < 0.0001 | ||
Lp-PLA2 (μg/L) | Q1 | 242 (9.2) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 237 (9.1) | 0.99 (0.83–1.18) | 0.90 | 1.01 (0.84–1.21) | 0.91 | 1.00 (0.83–1.20) | 0.99 | 1.00 (0.83–1.19) | 0.96 | |
Q3 | 267 (10.2) | 1.12 (0.94–1.33) | 0.21 | 1.14 (0.96–1.36) | 0.13 | 1.06 (0.88–1.27) | 0.53 | 1.05 (0.88–1.26) | 0.59 | |
Q4 | 280 (10.7) | 1.18 (0.99–1.40) | 0.06 | 1.17 (0.98–1.39) | 0.08 | 1.09 (0.90–1.32) | 0.37 | 1.08 (0.89–1.31) | 0.42 | |
Continuous model | 1.17 (1.02–1.35) | 0.03 | 1.17 (1.01–1.35) | 0.03 | 1.10 (0.94–1.28) | 0.25 | 1.09 (0.93–1.27) | 0.30 | ||
Lp-PLA2-A (nmol/min/ml) | Q1 | 230 (8.8) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 233 (8.9) | 1.02 (0.85–1.22) | 0.85 | 1.02 (0.85–1.22) | 0.84 | 1.00 (0.83–1.20) | 0.96 | 0.99 (0.82–1.19) | 0.91 | |
Q3 | 282 (10.8) | 1.25 (1.05–1.48) | 0.01 | 1.24 (1.04–1.47) | 0.02 | 1.18 (0.98–1.41) | 0.08 | 1.17 (0.97–1.40) | 0.09 | |
Q4 | 281 (10.8) | 1.25 (1.05–1.49) | 0.01 | 1.26 (1.05–1.50) | 0.01 | 1.18 (0.98–1.43) | 0.09 | 1.17 (0.97–1.42) | 0.10 | |
Continuous model | 1.30 (1.08–1.56) | 0.006 | 1.30 (1.08–1.57) | 0.006 | 1.20 (0.98–1.47) | 0.07 | 1.19 (0.97–1.46) | 0.09 | ||
YKL-40 (mg/L) | Q1 | 217 (8.3) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 238 (9.1) | 1.10 (0.92–1.32) | 0.31 | 1.05 (0.87–1.27) | 0.59 | 1.06 (0.88–1.29) | 0.53 | 1.05 (0.87–1.28) | 0.60 | |
Q3 | 253 (9.7) | 1.18 (0.98–1.41) | 0.08 | 1.05 (0.87–1.27) | 0.64 | 1.07 (0.88–1.29) | 0.52 | 1.05 (0.87–1.28) | 0.59 | |
Q4 | 318 (12.2) | 1.52 (1.28–1.81) | < 0.0001 | 1.26 (1.05–1.53) | 0.02 | 1.30 (1.07–1.58) | 0.008 | 1.28 (1.06–1.56) | 0.01 | |
Continuous model | 1.24 (1.15–1.35) | < 0.0001 | 1.13 (1.03–1.24) | 0.01 | 1.15 (1.05–1.26) | 0.004 | 1.14 (1.04–1.25) | 0.006 | ||
IL-6 + YKL-40 | Q1 | 248 (7.8) | Reference | – | Reference | – | Reference | – | Reference | – |
Q2 | 177 (8.7) | 1.13 (0.93–1.37) | 0.23 | 1.05 (0.86–1.28) | 0.66 | 1.08 (0.88–1.32) | 0.48 | 1.07 (0.87–1.31) | 0.51 | |
Q3 | 207 (10.1) | 1.34 (1.11–1.61) | 0.002 | 1.21 (1.00–1.45) | 0.05 | 1.24 (1.03–1.51) | 0.03 | 1.24 (1.02–1.50) | 0.03 | |
Q4 | 394 (12.3) | 1.66 (1.42–1.95) | < 0.0001 | 1.34 (1.12–1.59) | 0.001 | 1.38 (1.16–1.65) | 0.0004 | 1.37 (1.14–1.63) | 0.0007 |