From: Association of inflammatory markers with cerebral small vessel disease in community-based population
Variables | CSVD (Wardlaw)* | CSVD (Rothwell)†| ||||
---|---|---|---|---|---|---|
Absence of CSVD (n = 2121) | Presence of CSVD (n = 931) | P value | Absence of CSVD (n = 1785) | Presence of CSVD (n = 1267) | P value | |
Demographic data | Â | Â | Â | Â | Â | Â |
 Age, mean ± SD | 59.8 ± 6.1 | 64.6 ± 6.7 |  < 0.001 | 59.4 ± 6.1 | 63.7 ± 6.7 |  < 0.001 |
 Male, n (%) | 936 (44.1) | 483 (51.9) |  < 0.001 | 812 (45.5) | 607 (47.9) | 0.19 |
Risk factors, n (%) | Â | Â | Â | Â | Â | Â |
 Hypertension | 769 (36.3) | 545 (58.5) |  < 0.001 | 607 (34.0) | 707 (55.8) |  < 0.001 |
 Diabetes | 409 (19.3) | 250 (26.9) |  < 0.001 | 328 (18.4) | 331 (26.1) |  < 0.001 |
 History of dyslipidemia | 412 (19.4) | 200 (21.5) | 0.19 | 364 (20.4) | 248 (19.6) | 0.58 |
 History of heart disease | 149 (7.0) | 100 (10.7) | 0.001 | 121 (6.8) | 128 (10.1) | 0.001 |
 Current smoking | 439 (20.7) | 184 (19.8) | 0.56 | 381 (21.3) | 242 (19.1) | 0.13 |
 Current drinking | 382 (18.0) | 189 (20.3) | 0.14 | 324 (18.2) | 247 (19.5) | 0.35 |
 BMI, median (IQR) (kg/m2) | 23.5 (21.7–25.6) | 23.7 (21.6–25.8) | 0.41 | 23.5 (21.7–25.6) | 23.7 (21.6–25.8) | 0.35 |
Laboratory data, median (IQR) | Â | Â | Â | Â | Â | Â |
 Hemoglobin, g/L | 141.0 (132.0–151.0) | 141.0 (133.0–151.0) | 0.70 | 141.0 (132.0–151.0) | 141.0 (132.0–151.0) | 0.30 |
 White blood cell count (× 109/L)) | 5.9 (5.1–7.0) | 6.2 (5.2–7.2) |  < 0.001 | 5.9 (5.1–7.0) | 6.2 (5.2–7.1) | 0.002 |
 Neutrophil count (× 109/L) | 3.3 (2.7–4.1) | 3.5 (2.8–4.4) |  < 0.001 | 3.3 (2.7–4.1) | 3.5 (2.8–4.3) |  < 0.001 |
 Lymphocyte count (× 109/L) | 2.0 (1.6–2.4) | 2.0 (1.6–2.4) | 0.60 | 2.0 (1.6–2.4) | 2.0 (1.6–2.4) | 0.45 |
 Platelet count (× 109/L) | 208.0 (176.0–243.0) | 206.0 (171.0–241.0) | 0.29 | 207.0 (176.0–242.0) | 207.0 (173.0–242.0) | 0.54 |
 NLR | 1.65 (1.29–2.14) | 1.74 (1.33–2.29) | 0.001 | 1.65 (1.28–2.14) | 1.72 (1.34–2.25) | 0.001 |
 PLR | 102.9 (82.9–127.4) | 100.0 (80.6–127.1) | 0.42 | 102.6(82.5–127.3) | 102.3 (81.6–127.8) | 0.94 |
 SII (× 109/L) | 340.2 (253.2–459.2) | 353.0 (261.0–490.7) | 0.03 | 337.0 (252.6–455.9) | 353.4 (258.4–488.5) | 0.02 |
 Total cholesterol (mmol/L) | 5.24 (4.64–5.90) | 5.21 (4.54–5.92) | 0.26 | 5.25 (4.64–5.90) | 5.21 (4.56–5.92) | 0.19 |
 Triglycerides (mmol/L) | 1.44 (1.03–2.13) | 1.50 (1.08–2.15) | 0.18 | 1.45 (1.03–2.13) | 1.48 (1.06–2.15) | 0.29 |
 HDL (mmol/L) | 1.33 (1.14–1.57) | 1.32 (1.11–1.54) | 0.16 | 1.33 (1.14–1.57) | 1.32 (1.12–1.56) | 0.31 |
 LDL (mmol/L) | 2.75 (2.27–3.28) | 2.70 (2.16–3.29) | 0.043 | 2.76 (2.27–3.27) | 2.71 (2.23–3.30) | 0.25 |
 FBG (mmol/L) | 5.53 (5.19–6.04) | 5.68 (5.29–6.30) |  < 0.001 | 5.53 (5.19–6.03) | 5.64 (5.26–6.26) |  < 0.001 |
 HCY (mmol/L) | 10.5 (8.8–12.8) | 11.3 (9.4–14.2) |  < 0.001 | 10.5 (8.8–12.7) | 11.1 (9.2–13.8) |  < 0.001 |
Concomitant medication, n (%) | Â | Â | Â | Â | Â | Â |
 Antihypertensive | 449 (21.2) | 370 (39.7) |  < 0.001 | 345 (19.3) | 474 (37.4) |  < 0.001 |
 Lipid-lowing | 68 (3.2) | 51 (5.5) | 0.003 | 54 (3.0) | 65 (5.1) | 0.003 |
 Antidiabetic | 157 (7.4) | 117 (12.6) |  < 0.001 | 122 (6.8) | 152 (12.0) |  < 0.001 |
 Antiplatelet | 40 (1.9) | 40 (4.3) |  < 0.001 | 29 (1.6) | 51 (4.0) |  < 0.001 |
 Anticoagulant | 1 (0.05) | 3 (0.32) | 0.16 | 1 (0.06) | 3 (0.24) | 0.39 |