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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid

Fig. 3

ACP cystic fluid significantly affected the cell interaction between neurons in the mouse hypothalamus. A UMAP diagram for classification of the subclusters of cluster 3. B The expression of the Agrp gene and Npy gene in subcluster 3–3 (Agrp/Npy neurons) of the cystic fluid group was significantly higher than that of subcluster 3–3 (Agrp/Npy neurons) of the sham operation group. C Heatmap of the specific expression of ARC-specific marker genes in each subcluster. The 3–0 subcluster has no specific marker. The Prlr gene is specifically expressed in the 3–1 subcluster, the Sim1 gene and the Avp gene are specifically expressed in the 3–2 subcluster, the Agrp gene and the Npy gene are specifically expressed in the 3–3 subcluster, and the Ghrh gene is specifically expressed in the 3–4 subcluster. D Violin diagram of the marker genes specifically expressed in each subcluster of cluster 3. The Sst gene is specifically expressed in the 3–3 subcluster (Agrp/Npy neurons). E Intercellular interaction of Agrp–Mc3r is significantly enhanced between subcluster 3–3 (Agrp/Npy neurons) and subcluster 3–4 (Ghrh neurons) in the cystic fluid group (CF). In the interaction, Agrp/Npy neurons express the ligand gene Agrp, and Ghrh neurons express the receptor gene Mc3r

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Journal of Neuroinflammation

ISSN: 1742-2094