Fig. 6From: Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloidExpression of pathological markers of neurodegenerative diseases on mouse hypothalamus and childhood ACP tissue. A The results of immunohistochemistry. Amyloid-β (Aβ) is highly expressed in the mouse hypothalamus ARC after injection of ACP cystic fluid (3 V: third ventricle). B The results of immunohistochemistry. Amyloid-β (Aβ) is deposited in the whorl-like cells and in the gliosis zone of childhood ACP tissues. The red arrow indicates the cystic structure. The asterisk indicates that Aβ was deposited in whorl-like cells, and the black arrow indicates that Aβ was deposited in the gliosis zone. C–E Immunofluorescence results. Expression of CD74, APOE, and MHC-II in microglia in the gliosis zone of ACP. Asterisks indicate tumor tissue, Iba1 indicates microglia, and DAPI indicates nucleiBack to article page