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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3

Fig. 6

source channel was used for reconstruction of 3D-rendered images. Scale bar: 10 µm. Bb Quantification of Iba1+ microglia/macrophages. n = 5/group. Bc Quantification of CD206+CD16Iba1+ Resolve (resolution), CD16+CD206Iba1+ Pro (pro-inflammatory), CD16+CD206+Iba1+ Transit (transitional) and CD16CD206Iba1+ Rest (resting) microglia/macrophages in the striatum. n = 5/group. All data are presented as the mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. One-way ANOVA followed by Bonferroni’s post hoc, or Kruskal–Wallis test followed by Dunn’s post hoc

IL-13 regulates microglia/macrophages activation after stroke by inhibiting STAT3 activation. A Brain p-STAT3 and STAT3 expression were measured using Western blots 3d after tMCAO or sham operation. Aa Representative image of p-STAT3, STAT3 and β-actin. Ab Quantification of p-STAT3 and STAT3 expression in Western blots. n = 4–5/group. B Microglia/macrophages activation were measured 3d after tMCAO or sham operation. Ba Representative images of CD206 (green), CD16 (red), and Iba1 (white) immunostaining in the peri-infarct striatum. Scale bar: 50 µm. Four typical microglia were selected, and the absolute intensity of each

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