Fig. 10
From: A crosstalk between gut and brain in sepsis-induced cognitive decline
Ten days after the induction of experimental sepsis, Wistar rats were subjected to novel object recognition (NOR) test. A Locomotor activity and B. Recognition index. The recognition index decreased in the sepsis group compared to the control group, *p < 0.05. Evaluation of spatial memory task by Morris water maze. C Training trial, and D Probe trial. On day 2 of the training trial sepsis group taken more time to reach the platform as compared to control group, **p < 0.01. In the probe trial, sepsis-subjected rats demonstrated less time spent in the target quadrant, *p < 0.05, and n = 7–10 rats. The Pearson correlation between E Acetic acid vs. cognition, F Butyric acid vs. cognition, G Butyric acid vs. SUV uptake, H Butyric acid vs. TSPO at PFC, and I Butyric acid vs. TSPO in hippocampus, J Spleen weight vs. butyric acid, K Spleen weight vs. TSPO at PFC, L Spleen weight vs. TSPO at hippocampus, n = 4–6 rats. The results are expressed as the mean ± SEM