Fig. 2

In vivo PET imaging using TSPO specific radiotracer [¹¹C]PBR28. Representative summed images from the dynamic reconstruction of simultaneously acquired PET/CT scans from Wistar rats subjected to experimental sepsis by cecal ligation and perforation (CLP) and controls, 60 min after intravenous injection [¹¹C]PBR28. In the experimental sepsis model, the brain’s coronal, sagittal, and dorsal orientations show increased brain [¹¹C]PBR28 uptake than in controls. A Twenty-four hours and B Ten days after experimental sepsis induction. The SUV scale represents the standardized uptake value (SUV). Quantification of [¹¹C]PBR28 uptake detected in the experimental sepsis model was significantly higher compared to control based on measures of brain/muscle. C SUV 24 h after experimental sepsis induction. D SUV 10 days after experimental sepsis induction. The results are expressed as the mean ± SEM for n = 3–6 rats. *p < 0.05 compared to controls