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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

Fig. 3

Associations of neuroinflammatory markers with progression of disease severity. A Correlations between NPI-Q total score at baseline and disease severity progression as measured by change in CDR-SoB (ΔCDR-SoB) over time. B Associations between neuroinflammatory markers and cognitive status at baseline and changes of disease severity in the whole cohort measured by change in CDR-SoB (ΔCDR-SoB) at 18 and 36 months. Standardized β-coefficients and obtained by linear regression models are shown. C Moderation model evaluating the contribution of NPI-Q score, CSF sICAM-1 at baseline and their interaction to disease severity progression at 18 and 36 months (ΔCDR-SoB). β-Coefficients obtained by binary logistic regression models are shown. CDR-SoB, Clinical Dementia Rating Sum of Boxes; CRP, C-reactive protein; sICAM-1, soluble intracellular adhesion molecule-1; IP-10, 10-kDa IFN-γ induced protein; NPI-Q, Neuropsychiatric Inventory Questionnaire score; Inter., Interaction Between NPI-Q score and sICAM-1 concentration (NPI-Q score × sICAM-1 levels)

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Journal of Neuroinflammation

ISSN: 1742-2094