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Table 1 Demographic, clinical and biochemical characteristics of the study cohort

From: Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

Clinical characteristic NPI-Q = 0 (n = 48) NPI-Q > 0 (n = 39) P value
Sex, female, n (%) 34 (58.6) 24 (41.4) 0.360
Age, year, mean ± SD 68.19 ± 8.01 71.82 ± 6.1 0.022
Years of education ± SD 12.9 ± 2.3 12.1 ± 2.8 0.115
Cognitive function
 CDR, mean ± SD 0.2 ± 0.3 0.4 ± 0.3 < 0.001
 CDR-SoB, mean ± SD 0.34 ± 1.03 1.71 ± 2.04 < 0.001
 MMSE, ± SD 28.4 ± 1.92 26.03 ± 3.44 < 0.001
AD CSF biomarkers
 Aβ1–42, pg/ml, mean ± SD 939.72 ± 235.74 725.32 ± 257.72 < 0.001
 Tau, pg/ml, mean ± SD 240.08 ± 113.76 507.56 ± 354.85 < 0.001
 pTau181, pg/ml, mean ± SD 50.96 ± 21.87 75.32 ± 47.42 0.002
 pTau/Aβ ratio, mean ± SD 0.06 ± 0.03 0.13 ± 0.12 < 0.001
Biochemical measures
 ApoEε4, n (%ε4) 8 (27.6) 21 (72.4) < 0.001
 QAlb, mean ± SD 5.02 ± 1.71 6.95 ± 2.62 < 0.001
Neuropsychiatric status
 NPI score, mean ± SD 0.0 ± 0.0 5.74 ± 5.26 < 0.001