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Table 1 Demographic, clinical and biochemical characteristics of the study cohort

From: Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people

Clinical characteristic

NPI-Q = 0 (n = 48)

NPI-Q > 0 (n = 39)

P value

Sex, female, n (%)

34 (58.6)

24 (41.4)

0.360

Age, year, mean ± SD

68.19 ± 8.01

71.82 ± 6.1

0.022

Years of education ± SD

12.9 ± 2.3

12.1 ± 2.8

0.115

Cognitive function

 CDR, mean ± SD

0.2 ± 0.3

0.4 ± 0.3

< 0.001

 CDR-SoB, mean ± SD

0.34 ± 1.03

1.71 ± 2.04

< 0.001

 MMSE, ± SD

28.4 ± 1.92

26.03 ± 3.44

< 0.001

AD CSF biomarkers

 Aβ1–42, pg/ml, mean ± SD

939.72 ± 235.74

725.32 ± 257.72

< 0.001

 Tau, pg/ml, mean ± SD

240.08 ± 113.76

507.56 ± 354.85

< 0.001

 pTau181, pg/ml, mean ± SD

50.96 ± 21.87

75.32 ± 47.42

0.002

 pTau/Aβ ratio, mean ± SD

0.06 ± 0.03

0.13 ± 0.12

< 0.001

Biochemical measures

 ApoEε4, n (%ε4)

8 (27.6)

21 (72.4)

< 0.001

 QAlb, mean ± SD

5.02 ± 1.71

6.95 ± 2.62

< 0.001

Neuropsychiatric status

 NPI score, mean ± SD

0.0 ± 0.0

5.74 ± 5.26

< 0.001