Fig. 2
From: Network alterations underlying anxiety symptoms in early multiple sclerosis
A Longitudinal cortical thickness analysis. Workflow for longitudinal MRI morphometric analysis. B Anxiety-related atrophy maps across multiple sclerosis patients. Atrophy of the left PFC (peak region: rostral middle frontal lobe) was associated with anxiety scores measured by the HADS-A scale. C Atrophy network mapping. Generated atrophy maps are used in a seed-based functional connectivity analysis in a large dataset of healthy controls to find functionally connected regions. The atrophy network mapping approach identified the PFC, amygdala and hippocampus as brain regions functionally connected to the previously detected atrophied location