From: Network alterations underlying anxiety symptoms in early multiple sclerosis
Demographic and clinical data | Multiple sclerosis patients (n = 92) | ||
---|---|---|---|
Sex (female/male) | 62/30 | ||
Disease course at baseline (CIS/RRMS) | 21/71 | ||
Mean age at baseline MRI (SD) [years] | 34.4 ± 9.5 | ||
Mean age at disease onset (SD) [years] | 32.5 ± 9.5 | ||
Mean disease duration (SD) [years] | 1.9 ± 3.4 | ||
DMD (no/first line/second line)c | 24/54/14 | ||
Mean follow-up (SD) [years] | 2.4 ± 1.4 | ||
Mean EDSS score (SD) | 1.2 ± 1.1 | ||
Mean HADS-A score (SD) after 2 years | 5.5 ± 4.1 |
Volumetric analysis | Baseline | Follow-up | p value |
---|---|---|---|
Mean GM volume (SD) [ml] | 632 ± 629 | 614 ± 607 | 0.001a |
Mean TB volume (SD) [ml] | 1441 ± 1411 | 1436 ± 1411 | 0.008a |
Median T2 WM lesion volume (range) [ml] | 1.5 (0.1–83.2) | 2.0 (0.1–124.3) | 0.001b |