Network alterations underlying anxiety symptoms in early multiple sclerosis

Table 2 Brain volumes and their capability in predicting anxiety through SEM

Anxiety-related brain structures	Anxiety (HADS-A) after 2 years (n = 92 patients)		Anxiety (HADS-A) within the TMS–HD-EEG cohort (n = 18 patients)
Anxiety-related brain structures	s	p value	s	p value
Amygdala (left)	0.852	0.001	0.886	0.001
Amygdala (right)	0.825	0.004	0.803	0.003
Hippocampus (left)	0.836	0.002	0.858	0.002
Hippocampus (right)	0.816	0.006	0.782	0.003
Prefrontal cortex (left)	0.675	0.007	0.604	0.010
Prefrontal cortex (right)	0.633	0.011	0.704	0.006

Association between brain volumes of the regions within the identified functional network and HADS-A score in the main cohort and the TMS–HD-EEG cohort. The predictive power is expressed as SEM-derived standardized coefficient (s)
HADS-A Hospital Anxiety and Depression Scale-Anxiety subscale, TMS–HD-EEG transcranial magnetic stimulation and high-density EEG, SEM structural equation modeling

ISSN: 1742-2094