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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis

Fig. 1

Melatonin treatment protected mice from retinal injury after EAU induction. C57BL/6J mice immunized with IRBP1-20 were treated with melatonin at different dosages (0, 10, or 80 mg/kg/day) daily from day three after immunization. A Representative pictures of fundoscopic examination in the vehicle group and melatonin (10, 80 mg/kg/day) group at fourteen days after immunization (green arrow: vasculitis, red arrow: papilledema, blue arrow: linear lesions). B Representative pictures (H&E) of histopathologic examination in the vehicle group and melatonin (10 or 80 mg/kg/day) group (black arrow: inflammatory cells, red arrow: retinal folding with detachments, scale bars represent 200 μm). C The clinical scores of EAU were graded 14 days after immunization (n = 5). D The pathological scores of EAU via H&E were graded 14 days after immunization (n = 5). Representative data from three independent experiments. Significance was determined by one-way ANOVA. ***P < 0.001 vs. vehicle group

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