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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis

Fig. 3

Melatonin regulated Th1/Th17 and Treg cell balance in peripheral lymphoid organs of EAU mice. A–C The of CD4 + IFN-γ + , CD4 + IL-17A + , and CD25 + Foxp3 + T cells in the DLNs and spleens of EAU mice were evaluated by flow cytometry fourteen days after immunization (n = 5). D, E The lineage transcription factors of Th1 and Th17 in the DLNs and spleens of EAU mice were also analyzed by flow cytometry 14 days after immunization (n = 4). The representative data from three independent experiments. Significance was determined by unpaired t test (A–E). **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094