Fig. 8From: Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathwayMechanism by which asperosaponin VI improve CMS-induced depression. Stress induces a pro-inflammatory microglial phenotype (iNOS+-Iba1+ cells) in hippocampus, that causes reduced crosstalk between microglia and neuron, inflammation and synaptic dysfunction in the hippocampus, ultimately leading to depression-like behaviors. Asperosaponin VI may ameliorate the effects of stress by inducing microglia to adopt a PPAR-γ-dependent anti-inflammatory phenotype (Arg+-Iba1+ cells) which releasing anti-inflammatory and neuroprotective moleculesBack to article page