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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway

Fig. 3

Agomelatine alleviates neuronal inflammation in the DG region of LPS rats. A Immunofluorescent staining of Iba1 positive microglial cells within the DG region. Scale bar is 50 μm. (N = 6 per group). BD Q-PCR showing mRNA levels of pro-inflammatory cytokines. Band intensities were normalized to GAPDH. (N = 6 per group). E Western blot assays of protein expression levels of NF-κB P65 within the DG region (N = 6 per group). *P < 0.05, ***P < 0.001, LPS vs Control group; #P < 0.05, ###P < 0.001, LPS vs LPS + AGO (AGO, Agomelatine). Data are presented as means ± SEMs

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