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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway

Fig. 4

Agomelatine decreased the enhanced autophagy and synaptic damage in the DG region of LPS rats. A, B Western blot assays of protein expression levels of autophagy-related proteins within the DG region (N = 6 per group). C Representative electronic micrographs and summary of data showing the number of autolysosomes/cell. Arrows indicate autolysosomes. Scale bar is 1 μm. (D) Representative electron micrographs and summary of data showing the number of synapsis. Arrows indicate neuronal synapses. Scale bar is 1 μm (N = 6 per group). E Representative electron micrograph of DG neurons in rats from each group (N = 6 per group). Arrows indicate neuronal synapses. Scale bar is 0.2 μm.*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, LPS vs Control group; #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.001, LPS vs LPS + AGO (AGO, Agomelatine). Data are presented as means ± SEMs

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Journal of Neuroinflammation

ISSN: 1742-2094